cRABS

Aparajita Industries specializes in designing and manufacturing cRABS equipment tailored to the specific needs of each customer. Our flexible and adaptable designs ensure that our cRABS systems seamlessly integrate into any project. These closed, restricted access barrier systems provide effective protection for aseptic production processes where leak-tightness is not a requirement.

Specifically engineered to be compatible with pharmaceutical sterile filling lines, our cRABS offer superior protection for aseptic processes. They feature vertical unidirectional airflow to create a grade A zone, supported by a robust perimeter enclosure made from stainless steel. The system includes glass doors with inflatable seals, glove access, and specialized material transfer systems to maintain the highest standards of aseptic process protection.

• HEPA (H14) filter as per EN 1822) with a typical efficiency of >99.995% at 0.1 to 0.3 microns, providing ISO Class 5 air cleanliness as per ISO 14644-1
• PLC controller supervises all functions and monitors airflow and pressures in real-time
• Easy and Safe-change user friendly glove changing with zero risk of contaminating the work zone and/or pharmacy environment.
• Easy to clean one-piece work zone liner without any crevices.
• LED lamps Worm White / Natural White.
• For negatively pressured RABS, the work zone and pass-through chambers are under negative pressure to the room to maintain operator protection in the event of a breach in the system
• Positively pressured configurations are under positive pressure to the room to ensure product protection.
• Ergonomically angled front and oval / Round glove ports as per user requirement improve reach and comfort
• Ergonomically angled front and oval glove ports improve reach and comfort.

• Potent Filling Line Isolator
• Aseptic Formulation
• Contained powder handling
• Potent Formulation

• Easy installation, also on existing machines;
• Easy to validate (air flow, air classification, doors interlocks);
• Possibility to downgrade the production area to class B;
• Humidity and temperature inside the Closed-RABS can be controlled adopting a dedicated HVAC;

• Advanced mini-pleated supply H14 filters are tested to >99.999% efficiency for 0.3 micron particulates, significantly better than conventional filters.
• Laminar airflow within the work zone and pass-through enables recovery of chamber atmosphere to ISO Class 5 conditions within 3 to 5 minutes following a worse-case contamination event.
• The entire work zone air is changed 20-30 times per minute.
• Laminar (unidirectional) airflow within work zone and pass-through enables recovery of chamber atmosphere to Airlock pass-through ensures work zone sterility during material ingress and egress

• Work zone and pass-through pressures are monitored and displayed on the LCD screen with Alarm.
• Alarm package (pressure and airflow) is available for users with more sophisticated requirements.

• The unit’s fan system is designed for maximum energy efficiency and minimal maintenance. • Centrifugal, direct-drive, external rotor motors reduce operating costs.
• Ambient air is pulled through the inlet pre-filter located on top of the SLCRABS, which traps larger particles and extends the life of the supply HEPA filter. The prefilter traps larger particles and extends the life of the supply HEPA filter.
• Air from the top inlet and from work zone is pulled by the main fan, which creates positive pressure on the plenum and thus, downflow
• The work zone and pass-through interchange are under negative pressure to the room.
• The HEPA downflow filter creates a laminar and particle-free ISO Class 5 environment to protect the work material inside the main and pass-through.
• Approximately 10% of the recirculated air is exhausted through a HEPA filter filter to prevent heat build-up inside the RABS